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Sumatera utara
INDONESIA
Buletin Farmatera
Published by Universitas Muhammadiyah Sumatera Utara
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 10 Documents
 1 
Search results for , issue "Vol 6, No 2 (2021)" : 10 Documents clear
The Relationship of Cognitive Function to Nutritional Status and Blood Pressure in the Tegal Sari Mandala Village, Medan City Nanda Sari Nuralita; Amelia Eka Damayanti
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.3316

Abstract

Cognitive function is an intellectual function that plays a role in carrying out daily activities. The main risk factor for impaired cognitive function is hypertension. In addition, nutritional status also influences cognitive function disorders. Currently, in Indonesia, people with increased blood pressure and unbalanced nutritional status are often found, and without realizing it can have a bad influence on cognitive function. This is a categorical analytic study with a cross-sectional method, the sampling method is non-probability sampling with consecutive sampling types, with a sample of 40 people. There is a significant difference between the difference in blood pressure on cognitive function and there is also a significant difference between nutritional status on cognitive function with a P-value = 0.001. There is a significant difference between cognitive function on blood pressure and weight gain
Correlation of 25 Hydroxyvitamin D3 Levels with Blood Pressure and Lipid Profile, in Healthy Individuals Sari, Mutiara Indah; Sanny, Sanny
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6892

Abstract

Vitamin D is a prohormone and its level correlated with several cardiovascular diseases (CVD) biomarker such as blood pressure (systolic and diastolic) and lipid profile (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). This study aim to analyze correlation of serum 25-hydroxyvitamin D/ 25(OH)D levels with blood pressure and lipid profile in healthy subjects. This cross-sectional study was conducted on 39 healthy subjects from gym in Medan city. Measurement of vitamin D levels using Enzyme Linked Immunosorbent Assay (ELISA). Blood pressure was measured twice after 10 minutes rest using mercury sphygmomanometer. Lipid profile were measured by Cobas 6000 (C510+E610). Correlation of 25(OH)D with blood pressure and lipid profile were analyzed using Spearman correlation test. There was a significant correlation between of 25(OH)D levels and diastolic blood pressure (p = 0.047, r = -0.272), but not in systolic blood pressure and the lipid profile: TC, TG, HDL, and LDL, respectively.  (p = 0.159, p = 0.290, p = 0.425, p = 0.492, p = 0.156). This study concluded that 25(OH)D levels was correlated with diastolic blood pressure with low correlation, in that decreasing of 25-hydroxyvitamin D levels will increased diastolic blood pressure. 
Analisis Drug Related Problems Pada Pasien Benign Prostatic Hyperplasia (BPH) di RSUD Arifin Achmad Provinsi Riau Dimas Pramita Nugraha; Afdal Afdal; Anggit Armedo Pratama; Sandrina Kemala
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5528

Abstract

Abstrak.Prevalensi Benign Prostatic Hyperplasia (BPH) progresif dan meningkat secara linear seiring bertambahnya usia. Selain tingginya prevalensi penyakit komorbid pada populasi usia tua, pasien dengan BPH lebih cenderung diresepkan berbagai macam obat, yang mengarah pada peningkatan risiko interaksi obat-obatan, pasien BPH berisiko mengalami drug related problems (DRP). Tujuan penelitian ini adalah untuk menganalisis faktor-faktor terkait DRP pada pasien BPH. Penelitian ini merupakan studi retrospektif yang dilakukan di RSUD Arifin Achmad Provinsi Riau, data yang diambil dari Januari 2017 sampai dengan Desember 2019. Klasifikasi DRP menggunakan Pharmaceutical Care Network Europe Classification Version (PCNE) 5.01. Hubungan antara variabel kategorik di analisis menggunakan pearson chi-square. Pada studi ini sebagian besar pasien berusia tua (73,9%), bersuku Melayu (31,9%). Karakteristik klinis pasien BPH 84,5% memiliki masa menderita BPH kurang dari 1 tahun, komplikasi BPH yang paling banyak dijumpai adalah hematuria sebesar 34,3% dan penyakit komorbid yang paling banyak adalah hipertensi 26,6%. Sebagian besar pasien menggunakan monoterapi golongan Alpha blocker (89,3%). Dijumpai total 40 DRP, kategori DRP yang paling banyak dijumpai adalah masalah interaksi  berupa potensi terjadi interaksi obat (97,5%) diikuti masalah pemilihan obat berupa ketidaktepatan dalam duplikasi grup terapi (2,5%). Faktor yang berhubungan signifikan dengan terjadinya DRP pada pasien BPH adalah adanya komplikasi BPH (p=0,007, RR= 2,77), hipertensi (p= 0,011, RR= 2,04), dan polifarmasi (p=0,00, RR=4,79). Studi ini mengindikasikan bahwa masih terdapat DRP pada pasien BPH terutama yang berkaitan dengan potensi interaksi obat. DRP yang tidak terdeteksi dapat menyebabkan morbiditas terkait obat dan jika tidak diperhatikan  atau tidak ditangani, hal itu dapat menyebabkan kematian berterkaitan obat.
The Effect of Giving Red Dragon Fruit Juice on Changes in Leukocyte Levels and Fatigue Time in Maximum Intensity Physical Exercise Rika Rianingsih; Gusbakti Rusip
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5552

Abstract

Physical exercises contribute to oxidative tresses to cause fatigue and reduce the level of antioxidants in the body so that it affects physical fitness. Antioxidants are needed to neutralize free radicals and prevent damage to oxidative stress. This study aimed to determine the effect of red dragon fruit juice (Hylocereus polyrhizus) on leukocyte levels and tiring time in maximum intensity physical exercise. This research is the experimental research of the pre-test and post-test control group design. The research samples were divided into two groups, i.e. the control and treatment groups. Leukocyte levels were checked by using 2ml blood samples with hematology analyzers. Tiring time was determined by a treadmill test, in which the subject was asked to run until he/she reached maximum pulse. The minute the subject feels fatigued was documented as tiring time. This study showed significant results of leukocyte levels before and after treatment with a p-value of 0.005, tired time showed a p-value of <0.001, in which there was the lateness of tired time among the intervention group. Subjects who were given red dragon juice showed there was no increase in leukocyte levels and experienced lateness in the occurrence of tired time. That showed a better physical fitness level among the intervention group.
The Effect of Fasting Sunnah Mondays and Thursdays on Body Composition, Blood Pressure, and Blood Glucose Levels Eka Bebasari; Amru Sofian; Bayu Fajar Pratama
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5500

Abstract

Fasting is a form of non-pharmacological intervention to improve health. One of the sunnah fastings that is often done is fasting Monday and Thursday. There is still little research on the benefits of this sunnah fasting. This study is a quasi-experimental study to determine the effect of sunnah fasting on Mondays and Thursdays on body composition, blood pressure, and blood glucose levels. The research subjects were 19 Riau University students who were willing to fast every Monday and Thursday for 4 consecutive weeks (8 days of fasting), were healthy, and did not smoke. Measurement of research parameters was carried out before and after fasting. The results of this study showed differences in the average values of body composition (weight, body mass index, upper arm circumference, waist circumference, waist-hip ratio), systolic blood pressure, diastolic blood pressure, and blood glucose levels before and after fasting. The results of statistical analysis with paired t-test there were significant differences in the average values of upper arm circumference, waist circumference, diastolic blood pressure, and blood glucose levels before and after fasting (p <0.05), but there was no significant difference in body weight, index body mass, waist-to-hip ratio, and systolic blood pressure before and after fasting (p > 0.05). There is an effect of Monday and Thursday sunnah fasting on upper arm circumference, waist circumference, diastolic blood pressure, and blood glucose levels.
Antifungal Activity of Henna Leaf Extract (Lawsonia inermis linn.) Against Inhibition of Trichophyton rubrum Fungal Growth Cause Tinea Unguium Nanda Meutia; Imam Budi Putra; Nelva Karmila Jusuf
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.4768

Abstract

Tinea unguium is a common fungal nail infection. Most commonly caused by Trichophyton rubrum. It disturbs not only cosmetic figure, but also but also might have an impact on patient’s emotional, social and occupational functioning, lastly affecting the overall quality of life. The management of tinea unguium is still challenging. The therapy experienced many failures and recurrences. The aim of this research is to determine the presence of antifungal activity of Lawsonia inermis L. extract and to identify the extract concentration that can inhibit the fungal growth. This research is an experimental in vitro study with isolate from Microbiology Laboratory of Faculty of Medicine, Universitas Sumatera Utara. The Lawsonia inermis L. leaves extracted by maceration method. The antifungal assay was done using dilution method with various concentrations of (3,125%; 6,25%; 12.5%; 25%; 50%; 75% w/v). The mixtures of extract, suspension of Trichophyton rubrum and the media is incubated at 37ºC for 2-3 days. The mixture was streaked on SDA medium to determine the antifungal activity. The results indicates that Lawsonia inermis L. extracts has an antifungal effect, and with concentrations of 25%, 50% and 75% it can be use to inhibit the growth of Trichophyton rubrum qualitatively in vitro.
Potential of Flavonoids on Aortic Histopathological Improvement of ApoE-/- Mice With High-Fat Diet: A Systematic Literature Review Hilmi Adyatma; Niniek Hardini; Maria Selvester Thadeus
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6358

Abstract

Non-communicable diseases account for more than 36 million deathsevery year (63% of all deaths). Globally, non-communicable diseases (NCDs) thatcause the most deaths each year are cardiovascular diseases. One of thecardiovascular diseases is coronary heart disease. The cause of coronary heartdisease is acute coronary syndrome. More than 90% of acute coronary syndromes(ACS) are the result of atherosclerotic disorders. Therefore, research on thepotential of flavonoids to improve histopathology of atherosclerosis needs to becarried out in order to provide information about alternative drugs that can beused by patients. The purpose of this research using a systematic literature reviewresearch methodology is to identify the potential of flavonoids to improve aortichistopathology in ApoE-/- mice with a high-fat diet. Systematic literature reviewby conducting a literature search using PubMed and Google Scholar. Literaturethat discusses flavonoids, ApoE-/- mice, high-fat diet, aorta, and atherosclerosis.There were 8 studies which concluded that flavonoids could inhibit or reduce theenlargement or further formation of aortic atherosclerotic plaques in ApoE-/- miceon a high-fat diet. Flavonoids have the potential to inhibit or reduce theenlargement or further formation of aortic atherosclerotic plaques in ApoE-/- miceon a high-fat diet.
Hubungan asupan diet dengan penanda inflamasi pada penyandang obesitas Meriza Martineta; Dina Keumala Sari; Zaimah Z Tala; Nenni Dwi Aprianti Lubis
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6460

Abstract

Latar belakang: Obesitas merupakan keadaan tubuh yang disebabkan oleh keseimbangan energi positif yang erat hubungannya dengan pola diet. Penyandang obesitas mengalami inflamasi low-grade kronik dalam tubuh akibat produksi sitokin inflamasi dari jarinagan adiposa.  Tujuan penelitian ini adalah mengetahui adanya hubungan antara asupan diet dengan penanda inflamasi (high sensitivity C-reactive protein, Hs-CRP) penyandang obesitas. Methods:sebanyak 34 orang laki-laki dan wanita berusia 19-59 tahun dengan IMT ≥25,0 kg/m2dilakukan pemeriksaan darah Hs-CRP dan penilaian asupan diet menggunakan metode food frequency questionnaires (FFQ).  Hubungan antara asupan diet dengan Hs-CRP dinilai dengan menggunakan korelasi Spearman. Hasil: asupan kalori, protein, lemak, karbohidrat, serat, PUFA dan kolesterol tidak memiliki hubungan yang signifikan dengan Hs-CRP (p >0.05). Kesimpulan:Asupan diet tidak berhubungan dengan hs-CRP. 
Factors that Influencing Sputum Conversion at the End of Intensive Phase on TB-DM Patients at Medical Health Service in Medan Vani Gita Pertiwi; Bintang YM Sinaga; Dharma Lindarto
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.4767

Abstract

Tuberculosis and type 2 DM are the main problems of health in the world, including Indonesia. Many sputum conversion failures are found in TB-DM patients. This study aims to know about the factors that influence sputum conversion at the end of the intensive phase on TB-DM patients at the Medical Health Service in Medan. This research was carried out in a Specialized Lung Hospital and eight Health Centers in Medan. The Design of this study is observational analytic with a Cross-Sectional approach that took place in October-December 2019. Of 76 patients, there were 65 subjects (85.5%) with sputum conversion and 11 subjects (14.5%) without sputum conversion, the number of male patients was 48 subjects (63.2%), elderly were 51 subjects (67.1%), the normals BMI were 54 subjects (71.0%), patients with smoking were 4 subjects (5.3%), previous alcohol consumptions were 6 subjects (7.9%), current blood sugar levels >200 mg/dl are 23 subjects (30.2%) and the patients which using the anti-diabetes medication regularly were 62 subjects (81.6%). This study found that there was a significant relationship between alcohol, current blood sugar levels, and regularity using anti-diabetes medication with sputum conversion (p=0.036, p=0.001, p=0.001), while the factors that influence sputum conversion are alcohol and regularity using anti-diabetes medication (p=0.032, dan p=0.001).
HUBUNGAN POLIMORFISME GEN ANGIOTENSIN CONVERTING ENZYME DENGAN PERBAIKAN FRAKSI EJEKSI VENTRIKEL KIRI PADA PASIEN GAGAL JANTUNG KRONIK Ahmad Handayani; Isra Thristy; Meizly Andina
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5549

Abstract

Latar Belakang:  Angiotensin  converting  enzyme (ACE)  adalah  enzim  yang  beredar  dan  membran  terikat dalam sistem renin-angiotensin. Polimorfisme  adalah  keberadaan  dua  atau  lebih  alel  pada  sebuah  lokus  dalam populasi. Pada penderita gagal jantung dengan gangguan fungsi sistolik maka sistem RAA ini teraktifasi. Salah satu terapi utama pada gagal jantung adalah pemberian obat penyekat angiotensin converting enzyme. Penelitian ini bertujuan melihat hubungan polimorfisme gen angiotensin converting enzyme dengan perbaikan fraksi ejeksi ventrikel kiri.  Metode : Penelitian  ini  merupakan  penelitian  eksperimental  yang  menggunakan  rancangan studi prospektif observasional yang dilakukan terhadap 37 pasien gagal jantung dengan penurunan fraksi ejeksi di Rumah Sakit Mitra Medika Bandar Klippa Deli Serdang. Setiap pasien diperiksa ekokardiografi awal dan minimal 1 bulan setelah pengobatan dimana telah terlihat perbaikan klinis. Seluruh pasien mendapatkan pengobatan sesuai standar pedoman tatalaksana gagal jantung kronik menurut ESC/ PERKI. Hasil : Mayoritas subyek penelitian adalah laki-laki sebanyak 81% dan rata-rata usia pasien adalah 56 tahun. Polimorfisme gen ACE didominasi oleh gen II sebanyak 57%. Nilai FEVK pada pengukuran pertama rerata adalah 25.8% dan pada pengukuran kedua meningkat menjadi 34.4%.  Terlihat perubahan signifikan antara pengukuran FEVK I sebesar rata-rata 25% menjadi 34% pada pengukuran berikutnya (p < 0.05). Pada analisis hubungan terlihat bahwa polimorfisme gen ACE tidak berpengaruh terhadap perbaikan nilai FEVK. Kesimpulan : Pengobatan gagal jantung kronik dengan penurunan fraksi ejeksi terlihat memberikan efek yang siginifkan dalam penignkatan FEVK. Tidak terdapat hubungan polimorfisme gen angiotensin converting enzyme terhadap respon terapi pasien gagal jantung kronik pada penelitian ini.

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